Tokyo Institute of Technology

Homeostatic Mechanism Research Unit
Institute of Innovative Research

Noda Laboratory


  • 2023/1/15
    Our paper on “relationship between PTPRO activity and ectopic fat accumulation” was published in Life Sciences.
  • 2022/08
    Our review article on “brain mechanisms for water/salt intake control” was published in Proceedings of the Japan Academy, Ser. B, Physical and Biological Sciences.
  • 2021/7/29
    Professor Dr. Noda won the 23rd Toshihiko Tokizane Memorial Award.
  • 2020/11/10
    Our research on “water-intake control mechanisms” was published in Nature Communications.


We are currently conducting research aimed at elucidating the intracerebral mechanism of fluid homeostasis and blood pressure control. We are also conducting research on obesity (metabolic control).

Brain mechanisms controlling blood pressure

We are now promoting the study to elucidate the overall picture of brain mechanisms for ...

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Brain mechanisms controlling thirst and salt appetite

Terrestrial animals, including humans, have mechanisms that maintain body fluid homeostasis ...

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Research on obesity

Obesity is a major risk factor for type 2 diabetes, hypertension, dyslipidemia, and cardiovascular diseases.

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Masaharu Noda, Ph.D.
Specially Appointed Professor
Takashi Matsuda, Ph.D.
Specially Appointed Assistant Professor
Keiko Ikeda, Ph.D.
Visiting Associate Professor (Lecturer)
Fumiko Isoda.
Technical Support Staff
Yuko Kumeda.
Technical Support Staff
Mami Ishida.
Technical Support Staff
Yutaka Anzai.
Technical Support Staff
Shizuka Miyahara.
Technical Support Staff
Yukari Mutou.
Technical Support Staff
Yuka Shibuya.
Technical Support Staff
Youko Onoda.
Administrative Support Staff


(Representative recent ones)

  • Nomura K, Hiyama TY, Sakuta H, Matsuda T, Lin CH, Kobayashi K, Kobayashi K, Kuwaki T, Takahashi K, Matsui S, Noda M.
    [Na+] Increases in Body Fluids Sensed by Central Nax Induce Sympathetically Mediated Blood Pressure Elevations via H+-Dependent Activation of ASIC1a.
    Neuron 101:60-75. doi: 10.1016/j.neuron.2018.11.017. 2019.
  • Matsuda T, Hiyama TY, Niimura F, Matsusaka T, Fukamizu A, Kobayashi K, Kobayashi K, Noda M.
    Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organ.
    Nat. Neurosci 2017, 20, 230-241.
  • Hiyama TY, Watanabe E, Ono K, Inenaga K, Tamkun MM, Yoshida S, Noda M.
    Nax channel involved in CNS sodium-level sensing.
    Nature Neurosci. 2002, 5, 511-512.

Publication List


  • Location
    4259 Nagatsuta-cho, Midori-ku,
    Yokohama, Kanagawa
    226-8503 Japan
  • Nearest stations
    Suzukakedai Campus is a 5-minute walk from Suzukakedai Station on the Tokyu Denentoshi Line.
  • Mail


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